Accelerating Discovery

Our group has established strong collaboration with many important research groups in the US and Europe in addition to biotechnological companies. In Chile we have established two program grants to connect leading groups in the area of signal transduction, biomedicine and neuroscience (click in map).


Laurie H. Glimcher, Weill Cornell Medical College, New York, USA

Robert H. Brown, UMASS, Massachusetts , USA

Peter Walter, Howard Hughes Medical Institute and University of California, San Francisco, USA

Ana Maria Cuervo, Albert Einstein College of Medicine, NY, USA.

Claudio Soto, University of Texas Houston Medical School, Houston, Texas, USA.

Emily Cheng, Memorial Sloan-Kettering Cancer Center, New York, USA

Donna Armentano and Geoffrey Parsons, Genzyme Corporation, Framingham, Massachusetts, USA.

Anthony Letai, Dana-Farber Cancer institute, Boston, USA

Scott Oakes, USCF, USA

Feroz Papa, UCSF, USA

Doug Green, St Jude Children´s research Hospital, USA


Biomedical Neuroscience Institute, University of Chile.

The Biomedical Neuroscience Institute (BNI) constitutes a broad umbrella that consolidates a critical mass of leading basic and clinical neuroscientists, mathematicians and infrastructure to accomplish world-class scientific research. BNI provides a unified vision to explore the dynamic structural and functional organization of the brain under normal physiology from whole organisms to cells, and the mechanisms underlying disease. BNI operates under the guiding principles of (i) transdisciplinary research with members contributing with complementary expertise in cell and molecular neuroscience, neural development, morphogenesis, neuropathology, behavior, neural systems, applied mathematics and clinical research, (ii) a bottom-up multi-scale approach to study the function of genes from molecules to behavior in complementary animal models, and (iii) an integrated biomedical strategy to promote high-standard scientific contributions guaranteeing the transfer of scientific and medical impact to the community. Members are Andrés Couve (Director), PhD, molecular and cell biology of the mammalian neuron. Claudio Hetz (Deputy Director), and 9 other principal investigators including Lisette Leyton, Jimena Sierralta, Miguel Concha , Cecilia Hidalgo, Pedro Maldonado, Steffen Härtel, Mario Herrera-Marschitz, Manuel Kukuljan and Hernán Silva.

Center for Molecular Studies of the Cell (CEMC), University of Chile.

The central research theme of this Center is the study of signal transduction mechanisms operating in normal or aberrant cells. The problems addressed in the Center are relevant to understand nerve cell function, hormone action, muscle physiology, cellular death mechanisms and cancer. The specific research areas include studies of signal transduction mechanisms involved in calcium signaling, cancer, steroidogenesis, cell death, mineralocorticoid actions in cardiovascular diseases and hypertension, cellular stress response and neurodegenerative diseases. This center is form by several principal investigators including Andrew Quest, Andres Stutzin, Sergio Lavandero, Cecilia Hidalgo, Claudio Hetz, Luis Muchea, Enrique Jaimovich and Luigi Devoto.

Program grant from "Programa de Investigacion asociativa (PIA, Conicyt)"

To study the genetic bases of differential neuronal vulnerability in neurodegenerative diseases as Parkinson and ALS. This initiative connects six different labortorios through interdisciplinary interactions including Dr Felipe Court (Dierctor), Pablo Henny (Deputy Director) (P Catholic University of Chile, Patricio Manque and Andrea Calixto (Mayor University) and Soledad Matus (Neurounion Biomedical Foundation)

Other important national collaborators

Nibaldo Inestrosa, CARE Center, P Catholic University of Chile, Santiago.

Patricia Burgos, Universidad Austral de Chile, Valdivia.

Christian Gonzalez, University of Chile, Santiago.

Juan Pablo Henriquez, Universidad de Concepción, Concepción.

Brigitte Van Zundert Mathyssen, Universidad Andrés Bello, Santiago.

Alejandra Alvarez, P Catholic University of Chile, Santiago.

Alvaro Glavic, Universidad of Chile, Santiago, Chile.

Luis Cartier, Hospital El Salvador, Santiago, Chile.

Ricardo Arminsen, University of Chile, Santiago, Chile.


Afshin Samali, School of Natural Sciences, NUI Galway, Galway, Ireland,

Patrick Aebischer and Bernard Schneider, EPFL, Switzerland

Eric Chevet, INSERN, Université Rennes, France.

Beatrice Béatrice Bailly-Maitre, Université de Nice Sophia-Antipolis, France.

Guido Kroemer, Gustave Roussy Institute, Paris, France.

Patricia Agostinis, Universiteit Leuven, Belgium.

Jeroen Hoozemans,University Medical Center, Netherlands.

Geert Bultynck, K.U. Leuven, Leuven, Belgium


Kazuhiro Nagata, Kyoto University, Japan