NATIONAL

NAME	Chilean government funding agency FONDECYT
TITLE	Role of the unfolded protein response (UPR) in the progression of brain cancer
ROLE	Principal Investigator
ID	1220573. 2021-2025

 

NAME	FONDAP (Program grant)
TITLE	FONDAP Geroscience Center for Brain Health and Metabolism
ROLE	Associate Investigator
ID	15150012. 2020-2025

 

NAME	Chilean government funding agency FONDEF
TITLE	ProteoRescue: Terapia génica para tratar la esclerosis lateral amiotrófica (ELA) mediante una mejora proteostática
ROLE	Principal Investigator
ID	ID22I10120. 2022-2024

 

NAME	Desafío Global de Longevidad Saludable (NAM)
TITLE	Improving brain proteostasis as a strategy to reduce the adverse effects of psychosocial stress on the cognitive decline of the elderly
ROLE	Associate investigator
ID	NAM22I0057. 2022-2023

 

 

INTERNATIONAL

NAME	Air Force Office of Scientific Research
TITLE	Coping with environmental stress: at the interphase between neuronal proteostasis and brain physiology
ROLE	Principal Investigator
ID	FA9550-21-1-0096. 2021-2023

 

NAME	US Army Medical Research and Development Command (USAMRDC)
TITLE	Uncovering the Contribution of Cell-Type-Specific ER Proteostasis Networks to PD Pathogenesis
ROLE	Principal Investigator
ID	13204794. 2021-2024

 

NAME	Research Beyond Borders
TITLE	Defining the impact of MyDGF in the regulation of the Unfolded Protein Response (UPR) in cells undergoing ER stress
ROLE	Principal Investigator
ID	743352. 2023-2025

 

 

POSTDOC FELLOW

NAME	FONDECYT, Post-doctoral grant. Chile
TITLE	Control of lysosomal-mediated cell death by TMBIM1/RECS1: possible crosstalk with the BCL2 family
ROLE	Supervisor
PI	Mateus Milani
ID	45008. 2021-2024

 

NAME	FONDECYT, Post-doctoral grant. Chile
TITLE	Defining the contribution of IRE1 signaling to glioblastoma cell migration and invasion
ROLE	Supervisor
PI	Philippe Pihan
ID	45375. 2021-2024

 

 

 

 

NATIONAL

NAME	Chilean government funding agency FONDECYT
TITLE	Defining the role of ER stress signaling in C9orf7-mediated ALS
ROLE	Principal Investigator
ID	11180186. 2018-2021

 

NAME	Chilean government, Millennium Scientific Initiative (Program grant)
TITLE	Biomedical Neuroscience Institute (BNI)
ROLE	Director
ID	P09-015-F 2011-2021

 

NAME	CONICYT-Cooperation grant Chile-Brasil, Joint Call CNPq/ CONICYT
TITLE	Disrupted proteostasis as a shared mechanism of cognitive decline in normal aging and Alzheimer´s disease
ROLE	Principal investigator
ID	441921/2016­7 2017-2018

 

NAME	Chilean government funding agency FONDEF
TITLE	UPRplus: A novel gene therapy to treat Parkinson´s disease
ROLE	Principal Investigator
ID	D11I1007 2016-2019 (second period)

 

NAME	CELLUS-BNI
TITLE	Multineage-differentiating stress enduring stem cells derived from adipose tissue (Muse-AT)
ROLE	Principal Investigator
ID	2017-2018

 

NAME	Chilean government funding agency FONDEF
TITLE	Proteostaser-1: a gene therapy to reduce neurodegeneration and improve cognitive function in Alzheimers disease
ROLE	Principal Investigator
ID	ID16I10223 2016-2018

 

NAME	ECOS CONICYT Cooperation grant Chile-France
TITLE	Novel Roles of the unfolded protein response (UPR) in cancer
ROLE	Principal Investigator
ID	ECOS170032. 2018-2020

 

NAME	Chilean government funding agency FONDECYT
TITLE	The UPRosome: novel regulatory checkpoints and physiological outputs
ROLE	Principal investigator
ID	1140549 (2014-2018). Project ranked number one in the study section

 

NAME	Fundacion COPEC-UC
TITLE	Identification of neuroprotective compounds from chilean endogenous plants
ROLE	Principal investigator
ID	2013.R.40 (2014-2016)

 

NAME	CONICYT-Cooperation grant Chile-EEUU
TITLE	Gene therapy strategy to target the unfolded protein response in ALS
ROLE	Principal investigator
ID	USA2013-0003 (2014-2016)

 

NAME	ECOS-CONICYT – Cooperation grant Chile-France
TITLE	Functional study of the IRE1a interactome in cell migration and cancer
ROLE	Principal investigator
ID	C13S02 (2014-2016)

 

NAME	Chilean government funding agency FONDEF.
TITLE	UPRplus: A novel gene therapy to treat Parkinson´s disease.
ROLE	Principal investigator.
ID	D11I1007 (2012-2015)

 

NAME	Frick Foundation, Switzerland
TITLE	Defining the contribution of ER proteostasis disturbances to ALS
ROLE	Associate investigator
ID	20014-15 (2015-2016)

 

NAME	Ring Initiative, Chile
TITLE	Neuronal network initiative: Understanding selective neuronal vulnerability in neurodegenerative diseases
ROLE	Associate investigator
ID	ACT1109 (2013-2015)

 

NAME	FONDEQUIP
TITLE	Cellomics: An automatized platform for high throughput microscopy with biotechnological potential
ROLE	Principal investigator
ID	EQM120164 (2012)

 

NAME	Chilean government funding agency FONDECYT
TITLE	Defining the contribution of the disulfide isomerase ERp57 to the pathogenesis of Prion-related disorders
ROLE	Principal investigator
ID	FONDECYT 1100176 (2010-2014). Project ranked number one in the study section

 

NAME	FONDECYT Chile
TITLE	The tumor suppressor activity of Caveolin 1 is associated with an inhibition of the UPR
ROLE	Co-investigator
ID	FONCECYT 1090071 (2009-1013)

 

NAME	Chilean government funding agency FONDECYT
TITLE	Regulation of neuronal apoptosis by Abl in Alzheimer’s disease
ROLE	Co-investigator
ID	1080221 (2008-2012)

 

NAME	FONDAP (Program grant)
TITLE	FONDAP Center for Molecular Studies of the Cell (CEMC)
ROLE	Principal investigator
ID	FONDAP 15010006 (2007-2012)

 

NAME	Chilean government, Millennium Scientific Initiative (Program grant)
TITLE	Millennium Nucleus for Neural Morphogenesis (NEMO)
ROLE	Associate investigator
ID	Nucleo Milenio # P07-048-F (2009-2011)

 

NAME	Chilean government funding agency FONDECYT
TITLE	Regulation of the Unfolded Protein Response (UPR) by the stress sensor IRE1? and its role in neurological disorders
ROLE	Principal investigator and project manager
ID	1070444 (2007-2010). Project Ranked number one in the study section

 

NATIONAL – STAFF SCIENTISTS

 

NAME	Chilean government funding agency FONDECYT INICIACION
TITLE	Defining the role of IRE1 signaling in Cancer invasion and metastasis
ROLE	Hery Urra, Principal Investigator
ID	11180825. 2018-2021

 

NAME	CONICYT-USA cooperation grant
TITLE	Investigación traslacional en enfermedades neurodegenerativas y envejecimiento: estudio de factores de riesgo y biomarcadores inflamatorios
ROLE	Claudia Durán-Aniotz, Principal Investigator
ID	REDI170583

 

NAME	Chilean government funding agency FONDECYT INICIACION
TITLE	Targeting the UPR stress sensor IRE1 to treat Alzheimer’s disease
ROLE	Claudia Durán-Aniotz, Principal Investigator
ID	111160760. 2016-2019

 

INTERNATIONAL

NAME	US Army Medical Research and Development Command (DoD)
TITLE	Uncovering the Contribution of Cell-Type-Specific ER Proteostasis Networks to PD Pathogenesis.
ROLE	Principal Investigator
ID	13204794, Target Validation grant (2021-2025)

 

NAME	U.S. Air Force Office of Scientific Research
TITLE	Coping with environmental stress: at the interphase between neuronal proteostasis and brain physiology.
ROLE	Principal Investigator
ID	FA9550-21-1-0096, Target Validation grant (2021-2023)

 

NAME	The Michael J. Fox Foundation for Parkinson’s Research, USA.
TITLE	Gene therapy to restore ER proteostasis imbalance in Parkinson disease
ROLE	Principal Investigator
ID	12473, Target Validation grant (2017-2020)

 

NAME	Office of Naval Research- Global (ONR-G)
TITLE	A novel function of the Unfolded Protein Response (UPR) in learning and memory
ROLE	Principal Investigator
ID	N62909-16-1-2003 (2015-2017)

 

NAME	U.S. Air Force Office of Scientific Research
TITLE	Neuromorphic Inspired Science to Maximize Big Data Dynamic Problem Solving for Future intelligence, Surveillance, and Reconnaissance Operations
ROLE	Principal Investigator
ID	FA9550-16-1-0384 (2016-2017)

 

 

NAME	Muscular Dystrophy Association, USA
TITLE	Targeting the endoplasmic reticulum (ER) stress sensor IRE1 to treat SOD1-mediated ALS
ROLE	Principal Investigator
ID	382453 (2016-2019)

 

NAME	CDMRP ALS Research Program (ALSRP) Therapeutic Idea Award, USA
TITLE	Targeting the ER Stress Sensor IRE1 to Treat ALS in SOD1 and TDP43 pathogenesis
ROLE	Principal Investigator
ID	AL150111 (2016-2017)

 

NAME	European Commission R&D, MSCA-RISE 2016
TITLE	Interfere to Suppress or Promote IRE1 (INSPIRED) RISE Program
ROLE	Principal Investigator
ID	734749 (2016-2021)

 

NAME	Seed Money Grant, Leading House for the Latin American Region, Switzerland
TITLE	ER stress in post-traumatic distress order
ROLE	Co-Principal Investigator
ID	2018

 

NAME	ALS Therapy Alliance, USA
TITLE	Gene therapy to alleviate ER proteostasis alterations in ALS
ROLE	Principal Investigator
	2014-F-059 (2015-2017)

 

NAME	The Michael J. Fox Foundation for Parkinson’s Research, USA
TITLE	Targeting the ER stress sensor PERK for the treatment of Parkinson´s disease
ROLE	Principal Investigator
ID	9277. Target Validation grant (2014-2016)

 

NAME	Alzheimer’s Association, USA
TITLE	Defining the role of the Unfolded Protein Response in Alzheimer’s Disease
ROLE	Principal Investigator
ID	2012-2014

 

NAME	Muscular Dystrophy Association, USA
TITLE	A role of ER stress in wild-type SOD1 misfolding: A model for sALS?
ROLE	Principal Investigator and project manager
ID	MDA218655 (2012-2015)

 

NAME	ALS Therapy Alliance, USA.
TITLE	Defining the function of potein Disulfide Isomerases in ALS
ROLE	Principal Investigator and project manager (2012-2015)

 

NAME	The Michael J. Fox Foundation for Parkinson’s Research, USA
TITLE	Targeting the unfolded protein response (UPR) transcription factor XBP1 to alleviate neurodegeneration triggered by alpha-synuclein
ROLE	Principal Investigator
ID	Target Validation grant (2012-2013)

 

NAME	Christopher Reeve Spinal Cord Injury and Paralysis Foundation, USA
TITLE	targeting ER stress in Spinal Cord Injury
ROLE	Principal Investigator
ID	2015

 

NAME	North American Spine Society (NASS), USA
TITLE	Defining the role of the endoplasmic reticulum (ER) stress and the UPR in spinal cord injury
ROLE	Principal Investigator
ID	Research grant (2011-2012)

 

NAME	Alzheimer’s Association, USA
TITLE	Defining the role of the Unfolded Protein Response in Alzheimer s Disease
ROLE	Principal Investigator
ID	NIRG-10-173294 (2010-2012)

 

NAME	The Michael J. Fox Foundation for Parkinson’s Research, USA
TITLE	Targeting the Unfolded Protein Response (UPR) transcription factor XBP-1 to treat Parkinson’s
ROLE	Principal Investigator
ID	Target Validation grant (2010-2011)

 

NAME	GENZYME, USA
TITLE	Targeting BECLIN-1 to modulate autophagy mediated degradation of mutant SOD1 and other disease related misfolded proteins
ROLE	Principal investigator. SOURE: Sponsored Research Agreement (2010-2011)

 

NAME	ICGEB, International Center for Genetic Engineering and Biotechnology. Italy
TITLE	Role of the Unfolded Protein Response (UPR) in tumor suppression by caveolin-1
ROLE	Principal Investigator
ID	CRP/CHI08-03 (2009-2011)

 

NAME	CHDI Foundation, Inc, Research Grant, USA
TITLE	Defining the role of the Unfolded Protein Response in Huntington’s disease in vivo
ROLE	Principal Investigator (2008-2010)

 

NAME	Muscular Dystrophy Association, USA
TITLE	Targeting Autophagy for the removal of mutant SOD1 in ALS
ROLE	Principal Investigator and project manager
ID	MDA10036 (2008-2010)

 

NAME	The Michael J. Fox Foundation for Parkinson’s Research, USA
TITLE	A role of the UPR in Parkinson’s disease
ROLE	Principal Investigator
ID	2008-2009

 

NAME	National Parkinson Foundation, USA
TITLE	Defining the contribution of endoplasmic reticulum (ER) stress in Parkinson’s disease
ROLE	Principal Investigator and project manager
ID	2008-2009

 

NAME	GENZYME, USA
TITLE	Targeting Autophagy for the treatment of Protein Conformational Disorders affecting the nervous system
ROLE	Principal investigator
ID	2008-2009

 

NAME	High Q Foundation, discovery initiative, USA
TITLE	A role of Endoplasmic Reticulum Stress in Huntington’s Disease
ROLE	Principal Investigator and project manager
ID	2007-2008

 

NAME	Damon Runyon Cancer Research Foundation
TITLE	BCL-2 regulation of the endoplasmic reticulum stress response and apoptosis
ROLE	Principal investigator
ID	2004-2007

 

INTERNATIONAL – STAFF SCIENTISTS

 

NAME	Alzheimer’s Association Research Grant (AARG), USA
TITLE	Targeting the UPR stress sensor IRE1 to treat Alzheimer’s disease
ROLE	Claudia Durán-Aniotz, Principal Investigator
ID	2018-AARG-591107

 

POSTDOC FELLOW

 

NAME	Chilean Government Funding agency FONDECYT
TITLE	Identification of Chilean bioactive compounds from Ugni molinae to reduce abnormal aggregation in models of neurodegenerative diseases
ROLE	Patrocinante
PI	Alexis Rivas Ahumada
ID	FONDECYT 3170695

 

NAME	Chilean Government Funding agency FONDECYT
TITLE	Defining the Contribution of ERp57 mutants to the Pathogenesis of Amyotrophic Lateral Sclerosis
ROLE	Principal Investigator
PI	Danilo Bilches Medinas
ID	11150579 (2015-2018)

 

NAME	Chilean Government Funding agency FONDECYT
TITLE	Role of ER stress on the cell autonomous or non-autonomous effect trigerred by Wallerian degeneration
ROLE	Collaborator as Supervisor
PI	Gabriela Martinez
ID	FONDECYT 3150637

 

NAME	Chilean Government Funding agency FONDECYT
TITLE	Defining the contribution of the UPR stress sensor IRE1 in tumor and stromal cells to the development of brain cancer
ROLE	Collaborator as Supervisor
PI	Hery Urra Zúñiga (Co-advisor Andres Couve)
ID	FONDECYT 3160461 (2016-2018)

 

NAME	Chilean Government Funding agency FONDECYT.
TITLE	Modulation of mitochondrial metabolism by the ER stress sensor IRE1: Dual impact in calcium signaling and bioenergetics.
ROLE	Patrocinante
PI	Amado Carreras Sureda
ID	3150113 (2014-2017)

 

NAME	Chilean Government Funding agency FONDECYT.
TITLE	Role of insulin growth factor 2 (IGF2) in the neuroprotection observed by XBP1 deficiency
ROLE	Patrocinante
PI	Paula Garcia Huerta
ID	3150097 (2014-2017)

 

NAME	Chilean government funding agency FONDECYT
TITLE	Role of the Integrated Stress Response in the survival of dopaminergic neurons in pre-clinical models Parkinson’s Disease
ROLE	Principal Investigator
PI	María Gabriela Mercado
ID	11140738 (2014-2017)

 

NAME	Chilean Government Funding agency FONDECYT
TITLE	Regulation of an AD-like process by the UPR transcription factor XBP1 in vivo
ROLE	Supervisor
PI	Claudia Duran
ID	3140466 (2013-2016)

 

NAME	Chilean Government Funding agency FONDECYT
TITLE	Functional role of the UPR in the physiology of the nervous system
ROLE	Supervisor
PI	Pablo Mardones
ID	3140388 (2013-2016)

 

NAME	FONDECYT, Post-doctoral grant. Chile
TITLE	FINE TUNING OF THE UPR: functional analysis of the IRE1 interactome
ROLE	Collaborator as Supervisor
PI	Diego Rojas-Rivera
ID	3130365 (2012-2015)

 

NAME	FONDECYT, Post-doctoral grant. Chile
TITLE	Defining Mechanisms and the Role of Aggregation of Wild-type Superoxide Dismutase 1 (SOD1) in Amyotrophic Lateral Sclerosis
ROLE	Supervisor
PI	Danilo Medinas
ID	3130351 (2011-2014)

 

 

NAME	FONDECYT, Post-doctoral grant. Chile
TITLE	The role of ER-resident protein disulfide isomerases (PDIs) in the misfolding and neurotoxicity of mutant PrP and SOD1
ROLE	Supervisor
PI	Ute Woehlbier
ID	3110067 (2011-2013)

 

NAME	FONDECYT, Post-doctoral grant. Chile
TITLE	Assessment of the combinatorial role of loss-of-function of the endogenous prion protein and gain-of-toxic activity of the misfolded PrPE200K mutant protein in a zebrafish model of Creutzfeldt-Jakob disease
ROLE	Supervisor
PI	Nestor Guerrero
ID	3130757 (2012-2015)

 

 

NAME	FONDECYT, Post-doctoral grant. Chile
TITLE	Alpha-Synuclein internalization and ER stress response
ROLE	Supervisor
PI	Gabriela Mercado
ID	3120146 (2011-2014)

 

NAME	FONDECYT, Post-doctoral grant. Chile
TITLE	Defining the contribution of the Unfolded Protein Response (UPR) in the pathogenicity of mutant Huntingtin
ROLE	Supervisor
PI	Rene Vidal
ID	FONCECYT 3100039 (2009-2012)

 

NAME	CONICYT Insertion into the Academy fellowship, Chile
TITLE	Defining the role of ER stress and the Unfolded Protein Response (UPR) in the pathogenesis of ALS
ROLE	Supervisor
PI	Soledad Matus
ID	2010-2012

 

NAME	FONDECYT, Post-doctoral grant. Chile
TITLE	Induction of autophagy pathway protects against motoneuron degeneration in Amyotrophic Lateral Sclerosis induced by mutant SOD1 aggregation
ROLE	Supervisor
PI	Karen Castillo
ID	FONCECYT #3100112 (2009-2012)

 

NAME	ALS Association (ALSA), Post-doctoral grant. USA
TITLE	Defining the role of ER stress and the Unfolded Protein Response (UPR) in the pathogenesis of ALS
ROLE	Supervisor
PI	Soledad Matus
ID	ALSA 1829 (2009-2011)

 

NAME	FONDECYT, Post-doctoral grant. Chile
TITLE	GRINA, a new BI-1 homologue, regulates endoplasmic reticulum (ER) stress responses
ROLE	Supervisor
PI	Diego Rodriguez
ID	FONCECYT 3100033 (2009-2011)

 

NAME	FONDECYT, Post-doctoral grant. Chile
TITLE	The role of the Unfolded Protein Response on neurodegeneration in Amyotrophic Lateral Sclerosis
ROLE	Supervisor
PI	Soledad Matus
ID	FONCECYT 3085017 (2008-2010)