Our laboratory is committed to the study cellular strategies involved in adaptation to organelle damage, which are linked to several human diseases
Brain aging is the major risk factor for developing dementia, cancer and neurodegenerative diseases, and it is associated with a decreased buffering capacity of the proteostasis machinery.
We have developed new technologies using gene therapy and adeno-associated viruses to reprogram gene expression and enforce adaptive proteostasis repair pathways, with demonstrated success in multiple models of neurodegeneration including Alzheimer´s disease, Parkinson and Huntington´s disease, mechanical injury to the CNS, in addition to normal brain aging.